Very good so far, will continue using it.
Very good so far, will continue using it.
Bought for my partner and they love it.
Good value for money and fast delivery.
D-mannose is a simple sugar that blocks E. coli — responsible for 80%+ of UTIs — from adhering to the urinary tract wall. Without adhesion, bacteria are flushed out naturally. Combined with cranberry PACs and zinc, this is a comprehensive urinary health formula that works without disrupting the microbiome.
£19.5090 capsules · 3-month daily maintenance Free UK delivery over £30 · 30-day returns
Most people have only heard of cranberry juice for UTIs. D-mannose is the scientific mechanism behind why it partially works — isolated and concentrated.
The overwhelming majority of urinary tract infections are caused by E. coli bacteria adhering to the uroepithelial cells lining the urinary tract. Adhesion is the first step — without it, bacteria cannot establish infection.
D-mannose is a monosaccharide that competitively binds to the FimH adhesion proteins on E. coli that the bacteria use to attach to urinary tract cells. D-mannose saturates these binding sites, so the bacteria attach to D-mannose instead — and are then flushed out in the next urination. No adhesion. No infection.
Cranberry contains proanthocyanidins (PACs) which have a similar anti-adhesion mechanism against other E. coli strains. The combination of D-mannose and cranberry PACs addresses a broader range of bacterial adhesion pathways than either alone.
Bacteria use FimH proteins to bind to mannose receptors on the urinary tract wall.
D-mannose in the urine binds to FimH proteins — bacteria attach to D-mannose instead of the urinary wall.
Bacteria attached to D-mannose are expelled naturally during urination rather than establishing infection.
Unlike antibiotics, D-mannose acts only on E. coli attachment — beneficial bacteria are completely unaffected.
Competes with urinary wall mannose receptors for E. coli FimH binding. The most studied non-antibiotic compound for UTI prevention. Active in urine within 30 minutes of ingestion.
Proanthocyanidins from cranberry inhibit a different E. coli adhesion pathway (P-fimbriae), extending the anti-adhesion coverage beyond D-mannose alone.
Supports the immune response in the urinary tract and contributes to the maintenance of mucosal barrier integrity. EU-authorised claim: zinc contributes to normal immune function.
D-mannose vs antibiotics for UTI prevention: A clinical trial compared D-mannose powder with nitrofurantoin (antibiotic) and found D-mannose was significantly more effective at preventing recurrent UTIs, with far fewer side effects.
Cranberry PACs and E. coli: Research confirmed cranberry proanthocyanidins inhibited E. coli adhesion to uroepithelial cells via the P-fimbriae adhesion pathway.
Can D-mannose treat an active UTI or just prevent them?
Research shows D-mannose is effective for both prevention and treatment of E. coli UTIs. For an active infection, higher doses (2g, 3× daily) are studied. For prevention, 2g daily maintenance is the typical protocol. If you have an active infection with symptoms such as fever, consult your GP — antibiotics may be necessary.
Is it safe for diabetics?
D-mannose is a simple sugar but is metabolised differently to glucose and has minimal effect on blood sugar at supplemental doses. However, if you have diabetes or insulin resistance, consult your GP before use as individual responses vary.
Is this halal and vegan?
Yes. Fully halal certified, vegan, UK GMP manufactured. HPMC plant-derived capsule. Browse the women’s wellness range for complementary products.
D-Mannose · Cranberry PACs · Zinc · Halal · Vegan · UK GMP
£19.50 Free UK delivery over £30 · 30-day returns